Hydrocodone, Oxycodone, and Morphine Metabolism and …
Hydrocodone Metabolism . Greater than 50% of the total hydrocodone dose is metabolized by CYP-mediated phase 1 metabolism (Cone and Darwin, 1978; Cone et al., 1978; Park et al., 1982; Otton et al., 1993; Hutchinson et al., 2004; Barakat et al., 2012; Valtier and Bebarta, 2012).Hydrocodone is a substrate of both CYP2D6 and …