Manganese-enhanced magnetic resonance imaging is a technique that employs the divalent ion of the paramagnetic metal manganese (Mn2+) as an effective contrast agent to visualize, in vivo, the mammalian brain. As total achievable contrast is directly proportional to the net amount of Mn2+ accumulated in the brain, there is a great …
The use of manganese ions (Mn 2+) as an MRI contrast agent was introduced over 20 years ago in studies of Mn 2+ toxicity in anesthetized rats ().Manganese-enhanced MRI (MEMRI) evolved in the late nineties when Koretsky and associates pioneered the use of MEMRI for brain activity measurements as well as neuronal tract tracing ().Currently, …
1-weighted magnetic resonance imaging (MRI), specific to tissues in which the ion has accumulated. Manganese-enhanced MRI (MEMRI) uses a combination of ... Key Words: Manganese ion; Mn2+; magnetic resonance imaging; MRI; manganese-en-hanced MRI; MEMRI; brain; mouse; rat; rodent; olfactory; neuronal tracts; tract tracing; car-
nese injected in MEMRI studies can disrupt the homeostasis of other transition metals in mice. Keywords Manganese enhanced magnetic resonance imaging (MEMRI) Mouse brain Iron Copper X-ray fluorescence (XRF) Neutron activation analysis (NAA) Introduction Manganese-enhanced magnetic resonance imaging (MEMRI) is widely used in …
This special issue of NMR in Biomedicine on manganese-enhanced MRI (MEMRI) is aimed at providing the readers of this journal with an extensive review of some of the most prominent applications of MEMRI in biological systems. Written by several of the leaders in the field, the reviews and original research articles featured in this special …
Manganese-enhanced magnetic resonance imaging (MEMRI) Alan P. Koretsky* and Afonso C. Silva Laboratory of Functional and Molecular Imaging, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA Received 3 October 2004; Revised 6 October 2004; Accepted 6 October 2004
The use of manganese ions (Mn(2+)) as an MRI contrast agent was introduced over 20 years ago in studies of Mn(2+) toxicity in anesthetized rats (1). Manganese-enhanced MRI (MEMRI) evolved in the late nineties when Koretsky and associates pioneered the use of MEMRI for brain activity measurements (2) …
Manganese-enhanced magnetic resonance imaging (MEMRI) relies on contrasts that are due to the shortening of the T 1 relaxation time of tissue water protons that become exposed to paramagnetic ...
Studying Axonal Transport in the Brain by Manganese-Enhanced Magnetic Resonance Imaging (MEMRI) Methods Mol Biol. 2022:2431:111-142. doi: 10.1007/978-1-0716-1990-2_6. ... LLC, part of Springer Nature. Publication types Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't MeSH terms Animals
Manganese-enhanced magnetic resonance imaging (MEMRI) NMR Biomed. 2004 Dec;17(8):527-31. doi: 10.1002/nbm.940. Authors Alan P Koretsky ... aimed at providing …
To this end, we now report that manganese (Mn2+)-enhanced magnetic resonance imaging (MEMRI) can reflect brain region-specific HIV-1-induced …
Manganese-enhanced magnetic resonance imaging (MEMRI) relies on contrasts that are due to the shortening of the T 1 relaxation time of tissue water protons that become …
There is growing interest in the use of manganese-enhanced MRI (MEMRI) to detect neuronal activity and architecture in animal models. The MEMRI neuronal activity studies have been generally performed either by stereotactic brain injection or by systemic administration of Mn(2+) in conjunction with the disruption of the blood-brain barrier (BBB).
Axonal tracing is useful for detecting optic nerve injury and regeneration, but many commonly used methods cannot be used to observe axoplasmic flow and synaptic transmission in vivo.Manganese (Mn 2+)-enhanced magnetic resonance imaging (MEMRI) can be used for in vivo longitudinal tracing of the visual pathway. Here, we …
Conclusions: MEMRI has the potential to noninvasively distinguish different metastatic potential CRCs. However, the MnSOD expression is not correlated to malignant potential in CRC cells. Keywords: Colorectal cancer, Contrast-enhanced magnetic resonance imaging (MRI), Manganese, Metastatic potential, Manganese superoxide dismutase …
Sandvig A, Sandvig I, Berry M et al (2011) Axonal tracing of the normal and regenerating visual pathway of mouse, rat, frog, and fish using manganese-enhanced magnetic resonance imaging (MEMRI). J Magn Reson Imaging 34: 670–675. Article PubMed Google Scholar
Manganese-enhanced magnetic resonance imaging (MEMRI): methodological and practical considerations Afonso C. Silva,1* Jung Hee Lee,1 Ichio Aoki2 and Alan P. Koretsky1 1Laboratory of Functional and Molecular Imaging, National Institutes of Neurological Disorders and Stroke, Bethesda, MD, USA
Manganese-enhanced magnetic resonance imaging (MEMRI) relies on contrasts that are due to the shortening of the T 1 relaxation time of tissue water protons that become exposed to paramagnetic manganese ions. In experimental animals, the technique combines the high spatial resolution achievable by MRI with the biological information …
Manganese-Enhanced Magnetic Resonance Imaging Reflects Brain Pathology During Progressive HIV-1 Infection of Humanized Mice Aditya N. Bade1 & Santhi Gorantla1 & Prasanta K. Dash1 & Edward Makarov1 & Balasrinivasa R. Sajja2 & Larisa Y. Poluektova1 & Jiangtao Luo3 & Howard E. Gendelman1 & Michael D. Boska1,2 & Yutong Liu1,2 …
magnetic resonance imaging (MEMRI) is a powerful tool widely applied to verify the distribution of man-ganese in the mouse brain in vivo. In 1989, MEMRI was first described and proved to be a useful tool to study the neuronal activity or toxic manganese sno i ( Mn 2+) in the rodent brain, which based on the
The use of manganese ions (Mn 2+) as an MRI contrast agent was introduced over 20 years ago in studies of Mn 2+ toxicity in anesthetized rats ().Manganese-enhanced MRI …
Anatomical contrast enhancement by systemic Mn2+ injection has been studied in rodents (38–40, 43, 44), birds (57, 58), and primates (54, 55). The methods presented here are specifically designed for rat brain visualization based upon work developed in Koretsky's laboratory (44). …
Introduction. Cardiac magnetic resonance imaging has a major role in the diagnosis, evaluation of myocardial function and tissue characterization of a range of cardiovascular diseases 1 – 3.Conventional cardiac magnetic resonance with gadolinium enhancement allows for quantification of myocardial fibrosis which has utility in the …
Manganese-enhanced magnetic resonance imaging (MEMRI) relies on contrasts that are due to the shortening of the T 1 relaxation time of tissue water protons that become exposed to paramagnetic manganese ions. In experimental animals, the...
In contrast, manganese-enhanced magnetic resonance imaging (commonly termed MEMRI) can provide a noninvasive in vivo assessment of axonal transport at the macroscopic scale. MEMRI is based on two important physico-chemical properties of manganese (Mn 2+).
A key issue is whether sufficient accumulation of Mn2+ in heart cells for imaging can occur without cardiotoxicity, and findings to date indicate this is possible. This review examines the current status of Mn2+-enhanced MRI of heart with particular focus on the hypothesis that Mn2+ uptake can be interpreted in terms of heart function.
Mn 2+ Dynamics in the Brain. In MEMRI, the usual experimental process is to administer MnCl 2 (Figure 1B), allow the animals to move freely or impose a specific …
Manganese-enhanced MRI (MEMRI) is being increasingly used for MRI in animals due to the unique T1 contrast that is sensitive to a number of biological processes. Three specific uses of MEMRI have been demonstrated: to visualize activity in the brain and the heart; to trace neuronal specific connecti …
Manganese-enhanced magnetic resonance imaging (MEMRI) relies on the strong paramagnetism of Mn 2+.Mn 2+ is a calcium ion analog and can enter excitable cells through voltage-gated calcium channels. Mn 2+ can be transported along the axons of neurons via microtubule-based fast axonal transport. Based on these properties, MEMRI …
Saleem K. S., Pauls J. M., Augath M., et al. (2002) Magnetic resonance imaging of neuronal connections in the macaque monkey. Neuron 34, 685–700. Van der Linden A., Verhoye M., Van Meir V., et al. (2002) In vivo manganeseenhanced magnetic resonance imaging reveals connections and functional properties of the songbird vocal control …
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